TABLE 3.
Common Genes Used to Drive Expression in Genetic Models of Pancreatic Disease
| Gene | Conditional/Inducible Expression Systems Available | Target Cell Population |
|---|---|---|
| PDX1 | Cre CreER |
Acinar Ductal Endocrine Centroacinar |
| Pft1a/p48 | Cre CreERT |
Acinar Ductal Endocrine Centroacinar |
| Nestin | Cre | Acinar Acinar progenitor |
| Elastase-1 (Ela) | KrasG12D Cre CreERT2 tTA |
Acinar |
| proCPA1 | CreERT2 | Acinar |
| Mist1 | Cre CreERT2 |
Acinar |
| Rip | CreERT | Insulin-expressing cells |
| Insulin | Islet | |
| Neuregulin 3 (Ngn3) | Cre | Islet |