TABLE 6.
Complex Kras-based GEMMs
| GEMM | Lesions | Metastasis | Survival, mo | References |
|---|---|---|---|---|
| Pdx1-Cre; K‐Ras+/LSLG12D; Ink4a/Arflox/lox | PanIN and PDAC | Yes | 2 | 286 |
| Pdx1-Cre; K‐Ras +/LSLG12D; p53R172H/+ (KPC model) | PanIN and PDAC | Yes | 5 | 102 |
| Pdx1-Cre; K‐Ras +/LSLG12D; Ink4a/Arf−/− | PanIN and PDAC | Yes | 5 | 287 |
| Pdx1-Cre; K‐Ras +/LSLG12D; p53lox/lox | PanIN and PDAC | No | 3 | 287 |
| Pdx1-Cre; K‐Ras +/LSLG12D; p53lox/+; YFP | PanIN and PDAC | Yes | 5 | 104 |
| Pdx1-Cre; K‐Ras +/LSLG12D; p53lox/lox; Ink4a/Arf−/− | PanIN and PDAC | Yes | 2 | 287 |
| Pdx1-Cre; K‐Ras +/LSLG12D; Smad4lox/lox | IPMN and PDAC | Yes | 9 | 287 |
| Pdx1-Cre; K‐Ras +/LSLG12D; Brca2Tr/Δ11 | PanIN and PDAC | NA | NA | 288 |
| Pdx1-Cre; K‐Ras +/LSLG12D; p53R270H/+; Brca2Tr/+ | PanIN and PDAC | NA | <5 | 288 |
| Pdx1-Cre; K‐Ras +/LSLG12D; p53R270H/+; Brca2Tr/Δ11 | PanIN and PDAC | Yes | 2.5 | 288 |
| Pdx1-Cre; K‐Ras +/LSLG12D; Lkb1lox/lox | PanIN and PDAC | NA | 4.5 | 289 |
| Pdx1-Cre; K‐Ras +/LSLG12D; Notch1lox/lox | PanIN (high grade) | No | 3 | 290 |
| Pdx1-Cre; K‐Ras +/LSLG12D; Usp9x+/lox | PanIN and PDAC | NA | NA | 291 |
| Ptf1a(p48)-Cre; K‐Ras+/LSLG12D; p53lox/+ | PanIN and PDAC | Yes | 5 | 107 |
| Ptf1a(p48)-Cre; K‐Ras+/LSLG12D; p53lox/+; tdTomato | PanIN and PDAC | Yes | 5 | 53 |
| Ptf1a-Cre; K‐Ras+/LSLG12D; TGFβIIRlox/lox | PanIN and PDAC | Yes | 2 | 292 |
| Ptf1a-Cre; K‐Ras+/LSLG12D; Elastase‐TGF‐α | PanIN, IPMN, PDAC | Yes | 7 | 293 |
| Ptf1a-Cre; K‐Ras+/LSLG12D; Smad4lox/lox | MCN and PDAC | Yes | 8 | 294 |
| Ptf1a-Cre; K‐Ras+/LSLG12D; Notch2lox/lox | MCN, anaplastic, PDAC | No | >12 | 295 |
| Elastase-tTA; Tet‐O‐Cre; K‐Ras+/LSLG12Vgeo; p53−/− | PanIN and PDAC | Yes | 3–4 | 125 |
| Elastase-tTA; Tet‐O‐Cre; K‐Ras+/LSLG12Vgeo; p53lox/lox | PanIN and PDAC | Yes | 3–4 | 296 |
| Elastase-tTA; Tet‐O‐Cre; K‐Ras+/LSLG12Vgeo; Ink4a/Arflox/lox | PanIN and PDAC | Yes | 3–4 | 296 |
NA indicates not analyzed; IPMN, intraductal papillary mucinous neoplasm; MCN, mucinous cystic neoplasm