TABLE 7.

Pain Associated Behavior Analysis in Animal Models of Pancreatic Disease

Model	Species	Measure	References
Pancreatitis
Cerulein: mild acute (6–8 injections)	Mouse Rat	Abdominal Von Frey Open Field Activity	^{150,151,297,298}
Cerulein: severe acute (12 injections)	Mouse	Abdominal Von Frey	¹⁴⁸
Cerulein: chronic (6 inj./2days/6wks)	Mouse	Abdominal Von Frey Open field activity	^156,179
L-arginine	Rat	Abdominal Von Frey	²⁹⁹
DBTC (i.v.)	Rat	Abdominal Von Frey Abdominal Hargreaves Hot plate	^300–303
TNBS (intraductal)	Mouse Rat	Abdominal and hind paw Von Frey Electrically-evoked visceromotor reflex Open field activity Voluntary wheel running Vocalizations Catalepsy Elevated plus maze	^{147,149,152,156,158,159,195,304}
EtOH + HFD chronic (10 wks.) [Lieber DeCarli + high fat diet]	Rat	Abdominal Von Frey Hot plate	³⁶
Wistar/Bonn Kobori (WBN/Kob)	Rat	Home cage activity	³⁰⁵
Pancreatic cancer
Orthotopic xenograft	Mouse	Hunching Abdominal Von Frey Electrically-evoked visceromotor reflex	^155,306
Subcutaneous or intraneural xenograft	Mouse Rat	Hind paw Von Frey	^307,308
Orthotopic allograft	Mouse	Abdominal Von Frey Open field activity Home cage activity Voluntary wheel running	³⁰⁹
rEla1;SV40	Mouse	Hunching Vocalization	^310,311
KC mice (p48/pft1a-cre)	Mouse	Abdominal Von Frey	^312,313
KPC mice (p48/pft1a-cre)	Mouse	Hunching Open field activity	⁵³