TABLE 3.
Rate constant | Hereditary cluster 1 tumors (SDHx, VHL) (n = 7) | Hereditary cluster 2 tumors (RET, NF1) (n = 6) | Sporadic tumors (n = 13) |
K1 (mL⋅g−1⋅min−1) | 0.28 (0.10–3.25) | 0.44 (0.23–0.65) | 0.50 (0.18–1.01) |
k2 (min−1) | 0.79 (0.13–2.82) | 1.08 (0.54–1.50) | 0.99 (0.47–1.49) |
k3 (min−1) | 0.084 (0.015–0.170)* | 0.041 (0.015–0.062) | 0.025 (0.011–0.059) |
Vb (mL⋅mL−1) | 0.219 (0.080–0.738)† | 0.105 (0.037–0.128) | 0.151 (0.072–0.300) |
Significantly higher than sporadic tumor values (P < 0.01, Kruskal–Wallis with post hoc Dunn test).
Significantly higher than hereditary cluster 2 values (P < 0.01, Kruskal–Wallis with post hoc Dunn test).
Data are median followed by range in parentheses.