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. 2019 Jun;60(6):745–751. doi: 10.2967/jnumed.118.216796

TABLE 3.

18F-FDG Pharmacokinetic Rate-Constants for Primary and Metastatic PPGLs

Rate constant Hereditary cluster 1 tumors (SDHx, VHL) (n = 7) Hereditary cluster 2 tumors (RET, NF1) (n = 6) Sporadic tumors (n = 13)
K1 (mL⋅g−1⋅min−1) 0.28 (0.10–3.25) 0.44 (0.23–0.65) 0.50 (0.18–1.01)
k2 (min−1) 0.79 (0.13–2.82) 1.08 (0.54–1.50) 0.99 (0.47–1.49)
k3 (min−1) 0.084 (0.015–0.170)* 0.041 (0.015–0.062) 0.025 (0.011–0.059)
Vb (mL⋅mL−1) 0.219 (0.080–0.738) 0.105 (0.037–0.128) 0.151 (0.072–0.300)
*

Significantly higher than sporadic tumor values (P < 0.01, Kruskal–Wallis with post hoc Dunn test).

Significantly higher than hereditary cluster 2 values (P < 0.01, Kruskal–Wallis with post hoc Dunn test).

Data are median followed by range in parentheses.