Table 4. Top 20 canonical pathways enriched to extracellular pancreas HBPs in experimental AP using ingenuity pathways analysis.
The significance of the association between the datasets and the canonical pathway was measured by calculating the p-value using Fisher’s exact test to determine the probability of the association between the HBPs in the dataset and the canonical pathway.
| Canonical Pathways | -log (p-value) |
|---|---|
| Coagulation System | 14.9 |
| Acute Phase Response Signaling | 14 |
| Intrinsic Prothrombin Activation Pathway | 13.6 |
| LXR/RXR Activation | 13.4 |
| FXR/RXR Activation | 11.8 |
| Clathrin-mediated Endocytosis Signaling | 11.6 |
| Extrinsic Prothrombin Activation Pathway | 10.1 |
| Complement System | 9.89 |
| Actin Cytoskeleton Signaling | 9.64 |
| RhoGDI Signaling | 9.63 |
| G Beta Gamma Signaling | 9.38 |
| Role of Tissue Factor in Cancer | 9.33 |
| Ephrin Receptor Signaling | 8.93 |
| Signaling by Rho Family GTPases | 8.91 |
| Integrin Signaling | 8.34 |
| CXCR4 Signaling | 8.24 |
| Ephrin B Signaling | 7.93 |
| Virus Entry via Endocytic Pathways | 7.21 |
| Thrombin Signaling | 7.05 |
| Caveolar-mediated Endocytosis Signaling | 6.97 |