Table 1. Genotype and allele analysis of studied SNPs.
| SNP | Genotypes / Alleles | Cases (n = 241) | Controls (n = 516) | Odds ratio# (95% CI) | P-value | |
|---|---|---|---|---|---|---|
| miR-146a rs2910164 | CC | 12 | 29 | ref. | 0.669* | |
| CG | 85 | 166 | 1.24 (0.60–2.55) | |||
| GG | 144 | 321 | 1.08 (0.54–2.19) | |||
| C | 109 | 224 | 1.13 (0.81–1.37) | 0.329* | ||
| G | 373 | 808 | ||||
| D | GG / CG+CC | 144 / 97 | 321 / 195 | 1.11 (0.81–1.52) | 0.570** | |
| R | CC / CG+GG | 12 / 229 | 29 / 487 | 1.14 (0.57–2.27) | 0.863** | |
| ITGAM rs4597342 | CC | 105 | 270 | ref. | 0.079* | |
| CT | 110 | 201 | 1.41 (1.02–2.07) | |||
| TT | 26 | 45 | 1.49 (0.87–2.53) | |||
| C | 320 | 741 | 1.29 (1.02–1.63) |
0.014* | ||
| T | 162 | 291 | ||||
| D | CC / CT+TT | 105 / 136 | 270 / 246 | 1.42 (1.05–1.93) | 0.029** | |
| R | TT / CT+CC | 26 / 215 | 45 / 471 | 1.27 (0.76–2.11) | 0.363** | |
| IL12B rs1368439 | GG | 4 | 14 | ref. | 0.218* | |
| GT | 80 | 142 | 1.97 (0.63–6.19) | |||
| TT | 157 | 360 | 1.53 (0.50–4.71) | |||
| G | 88 | 170 | 1.13 (0.85–1.50) | 0.182* | ||
| T | 394 | 826 | ||||
| D | TT / GT+GG | 157 / 84 | 360 / 156 | 1.24 (0.89–1.71) | 0.209** | |
| R | GG / GT+TT | 4 / 237 | 14 / 502 | 1.65 (0.54–5.07) | 0.452** | |
| IL17RA rs1468488 *** | CC | 10 | 25 | ref. | 0.558* | |
| CT | 93 | 217 | 1.07 (0.49–2.31) | |||
| TT | 138 | 274 | 1.26 (0.59–2.70) | |||
| C | 113 | 267 | - | - | ||
| T | 369 | 765 | ||||
| D | TT/CC+TC | 138/274 | 103/242 | 1.18 (0.87–1.61) | 0.309** | |
| R | CC/TC+TT | Oct-25 | 231/491 | 1.18 (0.56–2.49) | 0.853** |
D–Dominant model of disease penetrance; R–Recessive model of disease penetrance
#OR for risk allele/genotype is presented (for 2x2 tables)
*P-values of Pearson’s χ2 test with permutation test correction
**Fisher’s exact test P-values
***rs1468488 was in Hardy–Weinberg disequilibrium for the controls; the allelic analysis could not be performed