Figure 1.

Development of a direct synthesis of sulfonamides starting from thiols and amines. (A) Established routes toward sulfonamides requiring prefunctionalized reagents. (B) Direct use of commodity chemicals to yield sulfonamides requires two steps. (C) Optimization of the electrochemical sulfonamide synthesis using thiophenol and cyclohexylamine. Reaction Conditions (Entry 1): thiophenol (2 mmol), cyclohexylamine (3.0 mmol), Me₄NBF₄ (0.2 mmol), CH₃CN/0.3 M HCl (20 mL, 3:1 v/v), C anode/Fe cathode, 5 min residence time, 700 μL reactor volume.