Figure 2.

Synthesis of sulfonamides. Substrate scope for the electrochemical sulfonamide synthesis by direct anodic coupling of thiols and amines. All yields are isolated and reproduced at least two times. Reaction conditions: thiol (2 mmol), amine (3.0 mmol), Me₄NBF₄ (0.2 mmol), CH₃CN/0.3 M HCl (20 mL, 3:1 v/v), C anode/Fe cathode, 5 min residence time, 700 μL reactor volume. ¹Reaction carried out in a batch reactor. Reaction conditions: thiol (3 mmol), amine (4.5 mmol), Me₄NBF₄ (3 mmol), CH₃CN/0.3 M HCl (30 mL, 3:1 v/v), C anode/Fe cathode, 24 h reaction time. ²Pyridine (2.0 mmol) was added as an additive. ³The corresponding disulfide was used as starting material. ⁴10 min of residence time instead of 5 min.