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A) HPV-associated SCC. A 48-year old woman with HIV (CD4+ count 560, VL 0) presented with a long-standing history of small lesions on buttocks and legs and two-week history of painful wound on the vulva. Hypopigmented thin papules were scattered on the legs and buttocks. B) Vulva, perineum, and perianal region had multiple exophytic, hyperpigmented and eroded plaques, .Biopsy at the border of an exophytic plaque demonstrated squamous cell carcinoma
