Table 2. Plasma proteins and structural MRI components.
| Study | Plasma Proteins | Z | Prot. IC | sMRI IC | Brain Regions (|z|>2.3) | r (p) |
|---|---|---|---|---|---|---|
| Cross-sectional | Interleukin-16 | 2.8 | A | A | Hippocampus, Posterior Cingulate, Inferior and Middle Temporal Gyrus, Thalamic nuclei | 0.41 (<0.0001) |
| Thyroxine-Binding Globulin | 1.7 | B | Amygdala, Anterior Hippocampus, Temporal Fusiform Cortex | 0.30 (0.002) |
||
| Alpha-2-Macroglobulin | 1.7 | |||||
| Apolipoprotein E | 1.7 | C | Fusiform Cortices, parahippocampal gyri, Right Inferior Temporal gyrus | 0.22 (0.02) |
||
| Brain Natriuretic Peptide | 2.6 | B | D | Right Inferior and middle Temporal Gyrus | -0.22 (0.02) |
|
| Pancreatic Polypeptide | 2.1 | |||||
| Peptide YY | -2.0 | |||||
| IgM | 2.0 | C | E | Thalamic Nuclei | -0.22 (0.02) |
|
| Eotaxin-3 | 1.7 | |||||
| Peptide YY | -1.6 | |||||
| Longitudinal | Bone Morphogenetic Protein 6 | 4.0 | A | A | Right fusiform cortex | -0.30 (0.04) |
| Matrix Metalloproteinase-9 | 3.1 | |||||
| Neuronal Cell Adhesion Molecule | 3.1 | |||||
| Fibroblast Growth Factor 4 | 2.5 | |||||
| Matrix Metalloproteinase-10 | -2.4 | |||||
| Superoxide Dismutase 1-Soluble | 1.7 | |||||
| von Willebrand Factor | 6.9 | B | B | Cingulate Gyrus | 0.30 (0.04) |
|
| C | Left fusiform cortex | -0.27 (0.04) |
||||
| E-selectin | 7.8 | C | D | Amygdala | 0.26 (0.04) |