Fig. 1. Comparison of R-spondin 1 (RSPO1) levels in human in relation to diverse metabolic parameters. (A) Comparison of RSPO1 levels between lean group and obese group. (B) Comparison of RSPO1 levels between insulin-sensitive group and insulin resistant group (IR). (C) Comparison of RSPO1 levels between non-diabetic participants and diabetic participants. BMI, body mass index; DM, diabetes mellitus.