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Time-varying effects of MGMT methylation level on progression-free survival (PFS) (solid line) with 95% confidence bands (dotted lines) according to Aalen’s additive hazard model. The steady slope of the cumulative effect of MGMT methylation level from time of diagnosis suggests an immediate effect of MGMT methylation level on PFS. After ∼18 months, the cumulative effect of MGMT methylation level on PFS levels out with very wide confidence bands.
