Figure 6. Responses against tau peptide pools in independent cohorts.
Total magnitude of response (sum of IFNγ and IL-5 responses) for tau megapool (a) and a pool of the 19 most immunodominant epitopes (b). a, PD (n=37), HCam (n=39), and HC35 (n=38). b, PD (n=25), HCam (n=24), and HC35 (n=19) Two-tailed Mann-Whitney test. Red circles, PD; Green squares, HCam and Blue triangles, HC35. Median ± interquartile range is indicated. c, Percentage IFNγ of total tau response per donor. PD (n=57), HCam (n=57) and HC35 (n=59). † indicates one sample t test for IFNγ polarization more than 50%. Two-tailed Mann-Whitney test for comparison between cohorts. Median ± interquartile range is indicated.