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. Author manuscript; available in PMC: 2020 Jun 18.
Published in final edited form as: ChemMedChem. 2019 May 14;14(12):1204–1223. doi: 10.1002/cmdc.201900084

Table 2.

Inhibition assay of IAV endonuclease by 5-aryl or 5-arylmethyl 6-(p-substituted phenyl)-3-hydroxypyridin-2(1H)-ones.

Compd 5-Aryl or
5-Arylmethyl		 graphic file with name nihms-1028470-t0037.jpg IC50 (nM) LE
kcal/(mol·NHA)
6 graphic file with name nihms-1028470-t0038.jpg C≡N 54[a] 0.433
7 graphic file with name nihms-1028470-t0039.jpg graphic file with name nihms-1028470-t0040.jpg 23[a] 0.403
24 graphic file with name nihms-1028470-t0041.jpg COOH 55 0.415
25 graphic file with name nihms-1028470-t0042.jpg C≡N 484 0.361
26 graphic file with name nihms-1028470-t0043.jpg C≡N 173 0.343
27 graphic file with name nihms-1028470-t0044.jpg C≡N 250 0.335
28 graphic file with name nihms-1028470-t0045.jpg graphic file with name nihms-1028470-t0046.jpg 54 0.369
29 graphic file with name nihms-1028470-t0047.jpg graphic file with name nihms-1028470-t0048.jpg 12 0.362
30 graphic file with name nihms-1028470-t0049.jpg graphic file with name nihms-1028470-t0050.jpg 81 0.324
[a]

Data were previously reported.[38]