Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Immunol. 2019 May 17;203(1):178–187. doi: 10.4049/jimmunol.1801657

Figure 4. Normal B lymphocyte development and class switch recombination in DNA-PKcsPQR/PQR and DNA-PKcsSD/SD mice.

Figure 4

(A) Representative flow cytometry analyses of the development in the bone marrow and spleen and in vitro class switch recombination of B cells from DNA-PKcs+/+, DNA-PKcsPQR/PQR, DNA-PKcsSD/SD as well as DNA-PKcsSD/SDATM−/− and ATM−/− mice. (B) Quantification of bone marrow PreB (B220+IgM-CD43-) vs ProB (B220+IgM-CD43+) B cell ratio in the bone marrow. More than three biological repeats were performed for each genotype. (C) The quantification of CSR kinetics in purified B cells activated in vitro. The bar represents the average and standard error. The p-value was calculated using student’s t-test. n.s. = not significant, and **<0.01.