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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Gastroenterology. 2019 Mar 15;157(1):163–178. doi: 10.1053/j.gastro.2019.03.018

Figure 6. PPARD activated the IFNG signaling pathway in the corpus of PPARD mice.

Figure 6.

(A) Heatmap of RNA sequencing transcriptome analysis for the corpus mucosa of the PPARD mice and WT littermates.

(B) Venn diagram of total differentially expressed genes (DEGs) for the mice described in panel A.

(C) Ingenuity Pathway Analysis for the 255 shared DEGs. The top three pathways were identified. IRF, interferon regulatory factor.

(D) Gene Set Enrichment Analysis plot of the IFNG activation signature based on 255 shared DEGs described in panel B.

(E-G) Validation results of IFNG signaling pathway–related gene measurements by qRT-PCR (E), immunostaining (F), and Western blot (G) in corpus mucosa of indicated mice at 25 weeks.

Scale bars, 100 μm (F).