A) OC formed in cultures of male BMMs treated with M-CSF + RANKL (30 ng/ml for both) and 0, 10 or 30 ng/ml of TNF. Cells were from WT or PAR1 KO male mice that were cultured for 4 days. N = 3 – 4 for each group. * Significantly different from WT, p < 0.05.
B) OC formed in cultures of male BMMs treated with M-CSF (30 ng/ml) + TNF (10 ng/ml) and 0, 10 or 30 ng/ml of RANKL. Cells were from WT or PAR1 KO male mice that were cultured for 4 days. N = 3 – 4 for each group. * Significantly different from WT, p < 0.05.