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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: J Immunol. 2019 May 20;203(1):105–116. doi: 10.4049/jimmunol.1801032

Figure 7.

Figure 7

WT or PAR1 KO male mice were injected once daily with TNF (2 μg) subcutaneously over the calvariae for 4 days and sacrificed 1 day later. Mice were also treated with control or N2 NRR Ab starting 3 days prior to the first TNF injection. Images are representative histology slides stained for TRAP. The graphs below the images show the ratio of eroded surfaces-bone perimeter, OC number (#)-bone perimeter, OC surface-bone surface and periosteum area (μm2). N = 6 – 9 per group. N = 3 – 4 per group. * Significantly different from respective WT control Ab-treated group, p < 0.01. # Significantly different from PAR1 KO control Ab-treated group, p < 0.01. Scale bar = 100 μm. All images are the same magnification.