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. 2019 Jun 12;9:204. doi: 10.3389/fcimb.2019.00204

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Copyright © 2019 Peng, Lu, Xie, Xu, He, Guo, Han, Wu, Dong, Lu, Liu, Cao and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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LEfSe revealed the temporal changes of gut microbial community. (A–C) LEfSe method was performed to compare taxa among each group at 0, 4, and 8 weeks, respectively. The bar plot lists the significantly differential taxa (p < 0.05) based on effect size (LDA score (log 10) > ± 2). Control is the normal control group treated with just normal saline. C+LTGP, C+MTGP and C+HTGP are the control groups treated with 158, 474, and 948 mg/kg TGP, respectively. CIA is the collagen-induced arthritis group treated with just normal saline. CIA+ LTGP, C+MTGP and C+HTGP are the collagen-induced arthritis groups treated with 158, 474, and 948 mg/kg TGP, respectively. CIA+TG is the collagen-induced arthritis group treated with 7.89 mg/kg TG.