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. 2019 Jun 12;9:204. doi: 10.3389/fcimb.2019.00204

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Copyright © 2019 Peng, Lu, Xie, Xu, He, Guo, Han, Wu, Dong, Lu, Liu, Cao and Gong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of TGP on T cell subsets in peripheral blood mononuclear cells of CIA rats. (A) Lymphocytes. FSC/SSC were gated. (B) CD4⁺ T lymphocytes. SSC/CD4 were gated. (C) Intracellular expressions of IFN-γ, IL-4, IL-17A, Foxp3 on CD3⁺ CD4⁺ T cells were gated. (D) Percentages of Th1, Th2 cells and Th1/Th2 ratio were analyzed. (E) Percentages of Th17 and Treg cells and Th17/Treg ratio were analyzed. Control is the normal control group treated with just normal saline. C+LTGP, C+MTGP and C+HTGP are the control groups treated with 158, 474, and 948 mg/kg TGP, respectively. CIA is the collagen-induced arthritis group treated with just normal saline. CIA+ LTGP, C+MTGP, and C+HTGP are the collagen-induced arthritis groups treated with 158, 474, and 948 mg/kg TGP, respectively. CIA+TG is the collagen-induced arthritis group treated with 7.89 mg/kg TG. Data indicate mean ± SEM. ^##P <0.01, ^#P <0.05 vs. Control; ^▴▴ P <0.01, ^▴ P <0.05 vs. CIA, indicating significant differences.