Table 1.
Summary of the flavonoids with MDR reversal effects and their application.
| Compound name | Functions | Application | References |
|---|---|---|---|
| Chrysin | ABC transporters regulation ROS induction STAT3 inhibition p53 inhibition |
Sensitizing mitoxantrone Sensitizing Dox, curcumin Sensitizing TRAIL Sensitizing cisplatin |
(70) (139, 142) (182) (185) |
| Baicalein | ABC transporters regulation ROS induction Hypoxia suppression CSCs inhibition |
Sensitizing docetaxel, paclitaxel Sensitizing TRAIL Sensitizing 5-FU Sensitizing mTORC1 inhibitor |
(77, 78) (137) (161) (165) |
| Apigenin | ABC transporters regulation CSCs inhibition Autophagy inhibition p53 inhibition |
Sensitizing docetaxel, doxorubicin Killing resistant CSCs Sensitizing Dox Sensitizing cisplatin |
(84–86) (166, 167) (177) (186) |
| Acacetin | ABC transporters regulation | Sensitizing Dox, SN-38 | (91, 92) |
| Wogonin | ABC transporters regulation ROS induction Hypoxia suppression CSCs inhibition |
Sensitizing Dox Sensitizing Dox, cisplatin Sensitizing Dox, cisplatin, paclitaxel Killing resistant CSCs |
(99) (147, 233) (162) (168) |
| Kaempferol | ABC transporters regulation EMT suppression |
Sensitizing cisplatin Sensitizing pemetrexed |
(107) (180) |
| Galangin | ROS induction STAT3 inhibition |
Collateral sensitivity Sensitizing cisplatin |
(157) (183) |
| Naringenin | ABC transporters regulation | Sensitizing daunomycin | (112) |
| Luteolin | ROS induction CSCs inhibition Cell cycle regulation Autophagy inhibition EMT suppression |
Sensitizing oxaliplatin, Dox Killing resistant CSCs Sensitizing tamoxifen Sensitizing cisplatin Sensitizing paclitaxel |
(151, 153–155) (169) (173) (178) (181) |
| Quercetin | ABC transporters regulation Hypoxia suppression CSCs inhibition Cell cycle regulation p53 inhibition |
Sensitizing Dox, paclitaxel Sensitizing Dox, cisplatin, etoposide Sensitizing gemcitabine, Dox Sensitizing Dox, ciaplatin Sensitizing 5-FU |
(119–122) (120, 163, 164) (170, 172) (175) (187) |
| Rutin | ABC transporters regulation | Sensitizing paclitaxel | (117) |
| Fisetin | ABC transporters regulation NF-κB inhibition |
Sensitizing cabazitaxel, paclitaxel Sensitizing TRAIL |
(123, 124) (50) |
| Scutellarin | Cell cycle regulation p53 inhibition |
Sensitizing cisplatin Sensitizing cisplatin |
(176) (188) |
| Icaritin | ABC transporters regulation Autophagy inhibition |
Sensitizing Dox Sensitizing epirubicin |
(128) (179) |
| Genistein | ABC transporters regulation ROS induction NF-κB inhibition |
To be explored Sensitizing radiation Sensitizing cisplatin, Dox, gemcitabine |
(131–133) (159) (189–191) |
| Biochanin A | ABC transporters regulation NF-κB inhibition |
Sensitizing mitoxantrone Sensitizing TRAIL |
(136) (196) |
| 7,3′,4′-Trihydroxyisoflavone | ROS induction | Sensitizing epirubicin | (160) |
| Tectorigenin | NF-κB inhibition | Sensitizing paclitaxel | (198) |