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. 2019 Jun 12;9:503. doi: 10.3389/fonc.2019.00503

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Copyright © 2019 Breun, Monoranu, Kessler, Matthies, Löhr, Hagemann, Schirbel, Rowe, Pomper, Buck, Wester, Ernestus and Lapa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Example of increased CXCR4 expression in bilateral vestibular schwannoma in NFII (patient #4). Display of transaxial CXCR4-directed positron emission tomography (PET), fused PET/computed tomography (CT), three-dimensional constructive interference in steady state (T2 CISS) magnetic resonance imaging (MRI; insert) and fused MRI/PET slices (arrows), which show increased chemokine receptor expression of bilateral vestibular schwannomas (arrows). Immunohistochemistry (IHC) of the left-sided tumor confirmed chemokine receptor expression [moderate (Score: 2) CXCR4 expression in 57% of tumor cells (Score: 3) resulting in an immunoreactive score of 6].