REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Synaptophysin, clone YE269	Abcam	Cat# ab32127; RRID: AB_2286949
E-Cadherin, clone 24E10	Cell Signaling Technology	Cat# 3195; RRID: AB_2291471
NFIB	Thermo Fisher Scientific	Cat# PA5-28299; RRID: AB_2545775
Calcitonin Gene Related Peptide (CGRP)	Sigma-Aldrich	Cat# C8198; RRID: AB_259091
Ki67	Abcam	Cat# ab15580; RRID: AB_443209
Anti-Cytokeratin, wide-spectrum/KWS	Agilent	Cat# Z0622; RRID: AB_2650434
Anti-phospho-Histone H3 (Thr3), clone JY325	Merck Millipore	Cat# 04-746; RRID: AB_1163442
Podoplanin	Abcam	Cat# ab11936; RRID: AB_298718
MASH1/ASCL1	BD Biosciences	Cat# 556604; RRID: AB_396479
ALDH1A1	Abcam	Cat# ab23375; RRID: AB_2224009
NEUROD1	Proteintech	Cat# 12081-1-AP
Phospho-Akt (Ser473)	Cell Signaling Technology	Cat# 4060; RRID: AB_2315049
Anti-4E-BP1, phospho (Thr37 / Thr46)	Cell Signaling Technology	Cat# 2855; RRID: AB_560835
Bacterial and Virus Strains
Ad5-CMV-Cre	Viral Vector Core Facility, University of IOWA Health Care	N/A
Chemicals, Peptides, and Recombinant Proteins
Cyclosporin A	Sigma-Aldrich	Cat# 30024
Cisplatin	Accord Healthcare Ltd	Dutch drug database ZI# 15683354
Neo-clear®	Merck Millipore	Cat# 109843
Sequencing Grade Modified Trypsin	Promega	Cat# V5111
Deposited Data
Mass spectrometry proteomics data	This study	ProteomeXchange: PXD010680
RNA-seq data	This study	European Nucleotide Archive: PRJEB28270
Experimental Models: Organisms/Strains
Mouse: Rb1flox/flox;Trp53flox/flox	Meuwissen et al., 2003	N/A
Mouse: Rb1flox/flox;Trp53flox/flox;CAG < Lox66Mycl-LucLox71 >	Huijbers et al., 2014	N/A
Mouse: Rb1flox/flox;Trp53flox/flox;CAG < Lox66Nfib-LucLox71 >	Semenova et al., 2016	N/A
Software and Algorithms
Living Image acquisition and analysis software	PerkinElmer	N/A
AxioVision 4 software	Carl Zeiss Vision	N/A
MaxQuant version 1.5.4.1	Cox and Mann, 2008	http://www.coxdocs.org
TopHat, version 2.1.0	Kim et al., 2013	https://ccb.jhu.edu/software/tophat/index.shtml
GraphPad Prism, versions 6 and 7.04	GraphPad Software	www.graphpad.com
Perseus software (version 1.6.1.3)	Tyanova et al., 2016	http://www.coxdocs.org
GSEA 3.0	Mootha et al., 2003, Subramanian et al., 2005	www.broadinstitute.org/gsea
STRING tool (version 10.5)	Szklarczyk et al., 2017	www.string-db.org
Cytoscape (version 3.4.0)	Shannon et al., 2003	www.cytoscape.org
DAVID tool (version 6.8)	Huang et al., 2009	david.ncifcrf.gov
Other
IVIS Spectrum In Vivo Imaging System	PerkinElmer	N/A
Zeiss Axioskop2 Plus microscope	Carl Zeiss Microscopy	N/A
Zeiss AxioCam HRc digital camera	Carl Zeiss Vision	N/A
Q Exactive Hybrid Quadrupole-Orbitrap Mass Spectrometer	Thermo Fisher Scientific	N/A
Ultimate 3000 nanoLC	Thermo Fisher Scientific	N/A
HiSeq 2000 Sequencing System	Illumina	N/A