Figure 4.

IFN-γ primed pMSCs but not unprimed significantly decrease plasmablast differentiation and IgG production. (A) Plasmablast frequencies were measured upon 7 days of co-culture of stimulated B cells with IFN-γ primed or unprimed pMSCs. Results are expressed as the % of viable CD19⁺ CD27^high CD38^high cells. (B) IgG concentration (ng/mL) was detected in the supernatants of stimulated B cells and IFN-γ primed or unprimed pMSCs by ELISA. N = 3 different B cell donors co-cultured with 1 pMSC donor Results are shown as means ± SD. *p < 0.05; **p < 0.01.