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. 2019 Jun 12;10:1310. doi: 10.3389/fmicb.2019.01310

Table 1.

The three data sets considered for florfenicol population pharmacokinetic analysis.

Data sets Sources Number of calves Total number of plasma samples Number of plasma samples < LLOQ LLOQ mg/L Range of sampling times (h) after dosing Products
A Sidhu et al., 2014 10 190 0 0.25 0–80 Nuflor®
B Company 16 240 12 0.05 0–192 Nuflor®
16 240 3 0.05 0–192 Generic (Norfenicol®)
C Unpublished 8 200 7 0.05 0–216 Nuflor®
Total 50 870 22

The 10 calves of the Sidhu' paper were healthy female Aberdeen Angus calves weighing 145–204 kg and aged 79–131 days. The 16 European stock calves from Company were 7 males and 9 females, aged ~5–9 months. They were randomly assigned to two treatment groups with 8 animals in each group, in a manner designed to minimize weight differences. All animals were healthy and physiologically normal. Weights ranged from 136 to 205 kg at selection. The eight unpublished calves were Holstein/Fresian cross-breed and weighed from 108 to 165 kg. Data reported as below the Level of Quantification (< BLQ) obtained after the drug administration was low (2.6%) and were ignored in the present analysis.