Table 1.

The three data sets considered for florfenicol population pharmacokinetic analysis.

Data sets	Sources	Number of calves	Total number of plasma samples	Number of plasma samples < LLOQ	LLOQ mg/L	Range of sampling times (h) after dosing	Products
A	Sidhu et al., 2014	10	190	0	0.25	0–80	Nuflor®
B	Company	16	240	12	0.05	0–192	Nuflor®
		16	240	3	0.05	0–192	Generic (Norfenicol®)
C	Unpublished	8	200	7	0.05	0–216	Nuflor®
	Total	50	870	22

The 10 calves of the Sidhu' paper were healthy female Aberdeen Angus calves weighing 145–204 kg and aged 79–131 days. The 16 European stock calves from Company were 7 males and 9 females, aged ~5–9 months. They were randomly assigned to two treatment groups with 8 animals in each group, in a manner designed to minimize weight differences. All animals were healthy and physiologically normal. Weights ranged from 136 to 205 kg at selection. The eight unpublished calves were Holstein/Fresian cross-breed and weighed from 108 to 165 kg. Data reported as below the Level of Quantification (< BLQ) obtained after the drug administration was low (2.6%) and were ignored in the present analysis.