Table 3.
AUC (0–96 h), average concentration (μg/ml), and Time (h) above possible MICs ranging from 0.25 to 2 μg/ml for selected quantiles and corresponding value of the T>MIC in % of 96 h, the claimed duration of action of Nuflor®.
| MIC (μg/ml) | Quantiles% | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 99 | 95 | 90 | 75 | 50 | 25 | 10 | 5 | 1 | ||
| Time above (h) MIC | 0.25 | 74.29 | 85.54 | 91.89 | 95.88 | 95.92 | 95.94 | 95.95 | 95.96 | 279.1 |
| Time above (h) MIC | 0.5 | 50.96 | 58.37 | 62.46 | 70.44 | 80.19 | 91.1 | 95.86 | 95.89 | 119.88 |
| Time above (h) MIC | 1 | 30.42 | 35.59 | 38.7 | 43.94 | 50.64 | 57.72 | 65.18 | 70.15 | 80.21 |
| Time above (h) MIC | 2 | 11.81 | 16.35 | 18.9 | 22.87 | 28 | 33.45 | 39.29 | 42.63 | 49.62 |
| Time above MIC (% of 96 h) | 0.25 | 77.38 | 89.1 | 95.72 | 99.87 | 99.92 | 99.94 | 99.95 | 99.96 | 290.73 |
| Time above MIC (% of 96 h) | 0.5 | 53.08 | 60.8 | 65.06 | 73.37 | 83.53 | 94.9 | 99.85 | 99.89 | 124.87 |
| Time above MIC (% of 96 h) | 1 | 31.69 | 37.07 | 40.31 | 45.77 | 52.75 | 60.12 | 67.89 | 73.07 | 83.55 |
| Time above MIC (% of 96 h) | 2 | 12.3 | 17.03 | 19.68 | 23.82 | 29.17 | 34.85 | 40.93 | 44.41 | 51.69 |
| AUC (0–96 h) | μg*h/ml | 88.5 | 103.4 | 113.1 | 130.5 | 153.6 | 181 | 211.1 | 232.5 | 291 |
| Average concentration (μg/ml) over 96 h | μg/ml | 0.92 | 1.08 | 1.18 | 1.36 | 1.6 | 1.89 | 2.2 | 2.42 | 3.03 |
Time above MICs (from 0.25 to 2 μg/ml) was computed from the 5,000 curves generated by MCS using the population model. Bold values indicates values for the selected PK/PD cut-off.