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. 2019 Jun 12;10:658. doi: 10.3389/fphar.2019.00658

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Copyright © 2019 Morroni, Sita, Graziosi, Ravegnini, Molteni, Paladini, Dias, dos Santos, Viegas, Camps, Pruccoli, Tarozzi and Hrelia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of donepezil and PQM130 treatments (0.5 or 1.0 mg/kg) on sinaptophysin levels in the Aβ_1-42O-injected mice. Synaptophysin mRNA relative expressions in the hippocampal samples (A). The mRNA relative expressions were determined through the 2^−ΔΔCt method and represented as percentage vs. the Sham/VH group. ACTB was used as control housekeeping gene. Synaptophysin activation was determined by Western Blotting in hippocampal samples at 33 kDa using β-actin (42 kDa) as loading control (B). Top: representative images of synaptophysin and β-actin expressions in hippocampus. Bottom: quantitative analysis of the Western blotting results for the synaptophysin levels. The values are expressed as mean ± SEM (n = 10) of each experimental group. (B: *p < 0.05 vs. Aβ/VH; ANOVA, post hoc test Bonferroni).