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. 2019 Jun 12;10:658. doi: 10.3389/fphar.2019.00658

Figure 6.

Figure 6

Effects of donepezil and PQM130 treatments (0.5 or 1.0 mg/kg) on tp53 mRNA relative expression (A) and caspase-9 (B) and caspase-3 (C) activations in the Aβ1-42O-injected mice. The tp53 mRNA relative expression was determined in hippocampal samples through the 2−ΔΔCt method and represented as percentage vs. the Sham/VH group. ACTB was used as control housekeeping gene. Caspase-9 and -3 activations were determined using a specific chromogenic substrate in the hippocampal samples. The values are expressed as mean ± SEM (n = 10) of optical density (OD) of each experimental group (A: *p < 0.05 vs. Aβ/VH, §§ p < 0.01 vs. Aβ/DON; B: # p < 0.05 vs. Sham/VH, *p < 0.05 vs. Aβ/VH; C: # p < 0.05 vs. Sham/VH, *p < 0.05 and **p < 0.01 vs. Aβ/VH; ANOVA, post hoc test Bonferroni).