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The effect of PKM1 and PKM2 on metabolomes of early differentiation (Day3). Embryoid body were constructed from Pkm1KI, and Pkm2KI embryonic stem cells (ESCs) and cultured for 3 days without LIF. Principal component analysis indicates good separation of Pkm1KI and Pkm2KI ESCs. Comparison of whole metabolites of Pkm1KI vs Pkm2KI ESCs is shown as loading factors (labeled colors).
