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Factors Influencing the Planning of a Preclinical Biodistribution Study of MSCs
| Pharmacodynamics-Related Factors |
| Mechanism of action and therapeutic effects |
| Target disease localization |
| Pathophysiology of the disease |
| Microenvironment |
| Pharmacokinetics-Related Factors |
| MSC-related: size, source, donor age and culture passages, culture conditions, and immunogenicity |
| Non-MSC related: labeling, detection method, animal size, and route of administration |
