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. 2019 May 30;16:283–297. doi: 10.1016/j.isci.2019.05.040

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This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Visualizing the Impact of Inhibiting F-Actin Filament Organization on TEM

Test of various inhibitors and their effects on cell polarity and actin filament organization during lymphocyte TEM. Serial images focusing on LifeAct localization in lymphocytes migrating on the HEV endothelium; only the LifeAct signal is shown with indicated times (min:s). Scale bar, 5 μm. Effects of latrunculin B (A), CK-666 (B), SMIFH2 (C), and blebbistatin (D) and control (E) on lymphocyte polarity, mobility, adherence, and TEM. LifeAct-GFP (green) channel and interpreted with gray scale. All confocal images shown are Z-projections from Ortho Slicer function in Imaris (4.8 μm/5 slices at 0.96 μm).