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. 2016 Jul 25;5:31–39. doi: 10.1016/j.reth.2016.06.003

Fig. 3.

Fig. 3

Effect of long cultivation of hESCs on component area of teratoma. SEES-2 cells at population doublings (PD) 21 and PD 104, and SEES-3 cells at PD 18-33 and PD 104-111 were implanted to generate teratomas. Histological components of teratomas were morphometrically analyzed as described in Materials and Methods and in the legend for Fig. 2. A. Percentage of cartilage area in teratomas generated by SEES-2 cells. Values between PD 21 and PD 104 were statistically insignificant with p < 0.01 by Student's t-test (p = 0.28). B. Percentage of cartilage area in teratomas generated by SEES-3 cells. Values between PD 18-33 and PD 104-111 were statistically insignificant with p < 0.01 by Student's t-test (p = 0.24). C. Percentage of epidermis area in teratomas generated by SEES-2 cells. Values between PD 21 and PD 104 were statistically insignificant with p < 0.01 by Student's t-test (p = 0.74). D. Percentage of epidermis area in teratomas generated by SEES-3 cells. Values between PD 18-33 and PD 104-111 were statistically insignificant with p < 0.01 by Student's t-test (p = 0.18). E. Percentage of intestine area in teratomas generated by SEES-2 cells. Values between PD 21 and PD 104 were statistically insignificant with p < 0.01 by Student's t-test (p = 0.32). F. Percentage of intestine area in teratomas generated by SEES-3 cells. Values between PD 18-33 and PD 104-111 were statistically insignificant with p < 0.01 by Student's t-test (p = 0.63).