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. 2019 Jun 18;9:8717. doi: 10.1038/s41598-019-45233-9

Figure 1.

Figure 1

Topology of KdpD and the amino acid sequence of the N-terminal region (aa 22–48) of KdpD that is involved in SRP interaction. The KdpD protein is a four-spanning membrane protein with two large cytoplasmic domains at the N-terminus and the C-terminus. The SRP signal peptide of KdpD is located in the N-terminal domain at residues 22–48 and contains five positively charged residues (red letters) and a Walker A motif (underlined). The mutations studied here are marked with a box. Site-directed mutagenesis was used to alter the amino acids in the peptide. The hydrophobicity of each mutant is indicated.