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. 2019 Jun 18;9:8708. doi: 10.1038/s41598-019-45043-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Spearman correlations between histologic METAVIR grade and multiparametric sonographic features. The level of fibrosis (METAVIR) was correlated with the numeric values of sonographic textural features (time = 13 weeks; (a) echointensity, (b) hepatorenal index, (c) heterogeneity and (d) anisotropy). Samples with insignificant fibrosis (F0, F1 from the control group) showed lower quantitative measures on ultrasound. There were positive correlation coefficients between the increasing level of fibrosis (F2 - F4 from the DEN group) and increasing ultrasound measures. Note the strongest correlation between anisotropy (variance between regions) and the progression of fibrosis, indicating an uneven pattern of development.