Fig. 1.

Histological morphology and differentiation subtypes were analyzed for pair-matched HCC tissues and corresponding stromas. (A) Typical features of well-differentiated (#2, 5, 7, and 9), middle-grade moderately differentiated (#3, 10, 11, 12, 13, and 14), and grade III poorly differentiated cases (#1, 4, 6, and 8), individually presented. (B) Hematoxylin–eosin staining for four HCC grade III tissues; ×100 fields indicate hemorrhagic necrosis, black arrows. In patient #1, anaplastic tumor giant cells are indicated with red arrows; in patients #4 and 6, with white arrows for mitoses. Original magnifications were ×100 and ×400. Scale bars, 100 μm and 50 μm.