Fig. 4.

PDX model developed by inoculation of fresh primary HCC tissues into NOD/SCID mice. (A) Flowchart of experimental procedures. (B) Risk factors identified by univariate F test. Of 20 variables, indicators of tumor location in the V and VI regions, impaired liver function, and CA125 showed significant p values. (C) Detailed histological morphology of large amounts of blood vessels (#6 and 8), thick trabecular (#6) and collagen in (#8) were reproduced in tumor grafts. Scale bars, 100 μm and 50 μm.