Table 2.
The incidence rate, crude and adjusted relative rate of different cancer types in diabetics compared to non-diabetics in ARIC cohort study
| Site of cancer | All | Diabetic | Non-Diabetic | Crude relative rate; 95% CI | Adjusted* relative rate; 95% CI | |||
|---|---|---|---|---|---|---|---|---|
| (N:14,119) | (N:1721) | (N:12,398) | ||||||
| N of new cases | Incidence rate (95% CI) | N of new cases | Incidence rate (95% CI) | N of new cases | Incidence rate (95% CI) | |||
| Skin | 287 | 2.13 (1.89, 2.39) | 27 | 1.67 (1.10, 2.43) | 260 | 2.20 (1.90, 2.50) | 0.76; 0.51,1.14 | 0.79; 0.51, 1.23 |
| Breast† | 169 | 2.30 (1.96,2.67) | 18 | 2.05 (1.22, 3.24) | 151 | 2.33 (1.97, 2.73) | 0.88; 0.54, 1.45 | 0.93; 0.54, 1.62 |
| Prostate | 162 | 2.60 (2.20, 3.01) | 12 | 1.62 (0.84, 2.84) | 150 | 2.77 (2.35, 3.25) | 0.59; 0.33, 1.06 | 0.51; 0.27, 0.97 ‡ |
| Colon & Rectum | 55 | 0.41 (0.31, 0.53) | 9 | 0.56 (0.25, 1.05) | 46 | 0.39 (0.28, 0.52) | 1.44; 0.71, 2.94 | 1.34; 0.60, 2.97 |
| Lung | 42 | 0.31 (0.22, 0.42) | 8 | 0.50 (0.21, 0.98) | 34 | 0.29 (0.20, 0.40) | 1.72; 0.80, 3.74 | 1.96; 0.83, 4.64 |
| Uterus | 38 | 0.52 (0.36, 0.71) | 7 | 0.80 (0.32, 1.64) | 31 | 0.48 (0.33, 0.68) | 1.67; 0.73, 3.79 | 1.47; 0.59, 3.69 |
| Head and Neck (HNC) | 35 | 0.26 (0.18, 0.36) | 1 | 0.06 (1.5 × 10 −6, 0.34) | 34 | 0.29 (0.20, 0.40) | 0.22; 0.03, 1.58 | 0.23; 0.03, 2.04 |
| Bladder | 34 | 0.25 (0.17, 0.35) | 1 | 0.06 (1.5 × 10 −6, 0.34) | 33 | 0.28 (0.19, 0.39) | 0.22; 0.03, 1.63 | 0.24; 0.03, 2.16 |
| Kidney | 14 | 0.10 (0.06, 0.17) | 1 | 0.06 (1.5 × 10 −6, 0.34) | 13 | 0.11 (0.06, 0.19) | 0.56; 0.07, 4.32 | 0.47; 0.05, 4.43 |
| Lymphatic System | 13 | 0.09 (0.05, 0.16) | 1 | 0.06 (1.5 × 10 −6, 0.34) | 12 | 0.10 (0.05, 0.18) | 0.61; 0.08, 4.71 | 0.75; 0.08, 7.07 |
| Stomach | 12 | 0.09 (0.05, 0.15) | 3 | 0.19 (0.04, 0.54) | 9 | 0.08 (0.04, 0.14) | 2.45; 0.66, 9.06 | 2.01; 0.47, 8.56 |
| Cervix | 9 | 0.12 (0.06, 0.23) | 1 | 0.11 (2.9 × 10 −6, 0.64) | 8 | 0.12 (0.05, 0.24) | 0.92; 0.12, 7.38 | 0.64; 0.06, 6.44 |
| Blood | 8 | 0.06 (0.03, 0.11) | 0 | 0.00 (0.00, 0.22) | 8 | 0.07 (0.03, 0.13) | 4. 6 × 10 −8; 0, NE c | 7 × 10−6; 0.00, NE |
| Thyroid | 4 | 0.03 (8 × 10 −6, 0.07) | 0 | 0.00 (0.00, 0.22) | 4 | 0.03 (9× 10−6, 0.09) | 4. 6 × 10 −8; 0, NE | 7 × 10−6; 0.00, NE |
| Ovary | 4 | 0.05 (0.02, 0.14) | 0 | 0.00 (0.00, 0.42) | 4 | 0.06 (0.02, 0.16) | 4. 6 × 10 −8; 0, NE | 7 × 10−6; 0.00, NE |
| Testicle | 2 | 0.03 (4 × 10 −6, 0.11) | 0 | 0.00 (0.00, 0.49) | 2 | 0.04 (4× 10−6, 0.13) | 4. 6 × 10 −8; 0, NE | 7 × 10−6; 0.00, NE |
| Others§ | 15 | 0.11 (0.06, 0.18) | 0 | 0.00 (0.00, 0.22) | 15 | 0.13 (0.07, 0.21) | ||
| Unknown | 28 | 0.21 (0.14, 0.30) | 1 | 0.06 (1.5 × 10 −6, 0.34) | 27 | 0.23 (0.15, 0.33) | ||
| All | 931 | 6.89 (6.46,7.35) | 90 | 5.57 (4.47, 6.84) | 841 | 7.07 (6.60, 7.56) | 0.79; 0.63–0.98 ‡ | 0.77; 0.60, 0.98 ‡ |
N number, CI Confidence Interval, NE Non-Estimable
*Adjusted for age, Body Mass Index, Physical activity and alcohol consumption using stratified poisson regression; †For women only; ‡P < 0.05; §Eye (1 case) Vagina (2 cases) Penis (1 case) Bone marrow (2 cases) Bone (2 cases) Gallbladder (2 cases) Spleen (1 case)