Fig. 5.

A locus in the left arm of Chr. IV confers a fitness advantage to CB4856. a Position of distant expression quantitative trait loci (eQTLs) (red circles) mapping to Chr. IV in a N2 × CB4856 cross⁴⁰; for simplicity, local eQTLs are not shown. Gray bars represent 1 − LOD (logarithm of the odds) drop confidence intervals. Position of the eQTL hotspot on the left end of Chr. IV is highlighted with a red arrow. This hotspot associates with the expression of 47 genes located across the C. elegans genome. b Allele frequencies of a C. elegans eXtreme QTL segregant pool expanded for 27 generations. Values correspond to the difference between the observed and the expected (0.5) in the absence of any selective force. The peak of the fitness locus on the left arm is highlighted with a red dashed vertical line