Fig. 1.

Location of mutated residues on folded back model of human β-cardiac myosin. a Model of the back-side view of the human β-cardiac myosin IHM (MS03 homology model²⁶), with the alpha-carbon backbones of the two S1 heads and the light chains shown as lines, and the S2 tail region represented by sticks. The four residues mutated in this study are represented by spheres. b Close up of region outlined by the dashed box in figure a showing the mutated residues R249Q (blue) and H251N (light blue) at the head-tail interface and D382Y (red) and R719W (blue) at the head–head interface