. 2019 May 11;18(1):243–254. doi: 10.1007/s40200-019-00409-y

Table 1.

This table depicts the role of miR29 in modulating cell signalling molecules affecting cardiac dysfunction. MCL-1, Myeloid leukaemia cell-1; IGF-1, Interstitial growth factor-1; BCL-2, B cell lymphoma 2; IL-6, Interleukin-6; TGF-β1, Transforming growth factor-β1

Hyperglycaemia		Cardiac dysfunction
Expression of miR29	Target	Cardiac dysfunction
Upregulation of miR29	Decreased mTORC1 signalling and MCL-1	Prevention of mTORC1 signal transduction pathway contributed for increased expression of miR29 and downregulation of MCL-1 gene in cardiomyocytes [105].
Downregulation of miR29	Increased IGF-1	IGF-1 is a direct factor involved in regulation process of angiogenesis in diabetic cardiomyopathy mediated via miR29 [98].
	Increased IGF-1 and BCL-2	miR29 downregulation expression pattern contributed to rise in IGF-1 and BCL-2 causing apoptosis of cardiomyocytes and cardiac fibrosis in cardiomyopathy [103].
	Increased TGF-β and IL-6	IL-6 is involved in cardiac fibrosis enhancement via targeting TGFβ1/miR29 loop [108].