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. 2019 Jun 12;10:1248. doi: 10.3389/fmicb.2019.01248

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Copyright © 2019 Du, Xu, Yu, Liu, Zhou, Yang, Li, Chen, Zhang, Xue and Cao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B. subtilis strain WS-1 inhibited diarrhea and death caused by E. coli in newborn piglets. Newborn piglets were first orally fed with TSB medium or TSB medium containing B. subtilis strain WS-1. At 3 days, all piglets were orally challenged with E. coli strain 4–1. The diarrhea rate (A) and survival rate (B) of newborn piglets post-challenge with E. coli between the control group and the B. subtilis strain WS-1 treatment group were recorded daily from the first day to the sixth day after challenge. The data are representative of two independent experiments. Data are represented as mean ± SD, n = 6 or n = 7.