FIGURE 1.

Effect of the GR_Ala610Val substitution on baseline metabolite levels (A) and on metabolic responses to dexamethasone treatment (B). (A) Baseline metabolite levels in plasma before treatment (0 h). Each bar represents n = 24 per genotype group. (B) Metabolite levels in plasma 3 h after treatment. The different groups were treated with saline (C; each bar represents n = 10 per genotype group), 10 μg/kg dexamethasone (D10; each bar represents n = 8 per genotype group), or 60 μg/kg dexamethasone (D60; each bar represents n = 6 per genotype group), respectively. Results are presented as least-squares means + SEM. Bars sharing the same superscript are not significantly different at p < 0.05. For Glucose main effect of genotype × treatment interaction was significant at p < 0.05.