Table 1.

Comparison of estimated genotype and genotype × treatment interaction effects of the GR_Ala610Val substitution on the expression of selected genes.

			Genotype (GinC)1		Genotype × D10 (G × D10)2		Genotype × D60 (G × D60)3
Gene	Ensembl ID	Method	log2 FC4	p-value	log2 FC4	p-value	log2 FC4	p-value
CEBPB	ENSSSCG00000034207	RNA-seq	0.298	0.027	0.084	0.645	-0.024	0.921
		qPCR	0.117	0.760	-0.207	0.718	0.073	0.907
FOSL2	ENSSSCG00000032527	RNA-seq	0.438	0.003	-0.532	0.010	-0.296	0.226
		qPCR	0.181	0.340	0.039	0.890	-0.106	0.731
PCDHB7	ENSSSCG00000036961	RNA-seq	2.777	<0.001	-0.019	0.976	-2.526	0.006
		qPCR	0.934	0.011	-0.089	0.866	-1.091	0.063
PFKFB3	ENSSSCG00000011133	RNA-seq	-1.028	0.006	1.298	0.011	0.368	0.600
		qPCR	-0.844	0.065	1.177	0.085	0.411	0.575
PPARGC1A	ENSSSCG00000029275	RNA-seq	0.351	0.013	-0.344	0.075	-0.302	0.206
		qPCR	0.278	0.300	-0.159	0.691	-0.278	0.524
SCARA5	ENSSSCG00000009672	RNA-seq	0.492	0.038	-0.900	0.008	-0.757	0.059
		qPCR	0.742	0.006	-0.993	0.013	-1.134	0.010
FAXDC2	ENSSSCG00000017068	RNA-seq	-0.599	0.016	0.948	0.006	1.149	0.010
		qPCR	-0.595	0.151	0.941	0.091	0.893	0.139
GCK	ENSSSCG00000016751	RNA-seq	-1.102	0.012	1.225	0.041	-0.030	0.968
		qPCR	-1.233	0.043	1.414	0.077	0.779	0.365
SLC17A3	ENSSSCG00000037547	RNA-seq	0.476	0.046	-1.142	0.001	-1.018	0.055
		qPCR	0.291	0.443	-0.576	0.231	-0.611	0.243

¹Genotype (ValVal vs. AlaAla) effect on baseline expression estimated in the saline control (C) group. ²Genotype × treatment interaction estimated by contrasting D10 treatment (10 μg/kg dexamethasone) effects between the genotype groups (expression change between D10 vs. C in ValVal compared to D10 vs. C in AlaAla). ³Genotype × treatment interaction estimated by contrasting D60 treatment (60 μg/kg dexamethasone) effects between the genotype groups (expression change between D60 vs. C in ValVal compared to D60 vs. C in AlaAla). ⁴Log2 fold change differences between ValVal vs. AlaAla. Bold values highlight p < 0.05.