Table 2.
Effect of the GRAla610Val substitution on baseline hepatic expression of selected genes in an independent cohort.
| LSM ± SE1 |
|||||
|---|---|---|---|---|---|
| AlaAla | AlaVal | ValVal | |||
| Gene | ENSEMBL_ID | n = 18 | n = 41 | n = 21 | p-value2 |
| PCDHB7 | ENSSSCG00000036961 | 8.01a ± 0.16 | 8.31a,b ± 0.10 | 8.55b ± 0.15 | 0.042 |
| PFKFB3 | ENSSSCG00000011133 | 11.81 ± 0.29 | 11.86 ± 0.19 | 11.69 ± 0.28 | 0.886 |
| PPARGC1A | ENSSSCG00000029275 | 12.80a ± 0.17 | 13.13a,b± 0.11 | 13.43b ± 0.16 | 0.031 |
| SCARA5 | ENSSSCG00000009672 | 12.09 ± 0.19 | 11.63 ± 0.12 | 11.61 ± 0.18 | 0.109 |
1Estimated least square means ± standard error of estimate; log2 transformed expression values. 2p-value of the main effect of genotype. Significant differences between LSM are indicated by different superscript within a row (a,b,c and p ≤ 0.05). Bold values highlight p < 0.05.