Table 1.

Tissue expression of human HS3STs.

Enzyme	Expression in normal tissues	Potential role in cancer
HS3ST1	cerebellum (high), spleen (high), cerebral cortex, kidney, lung, stomach, small intestine, colon, testis, liver, heart, pancreas, placenta (13, 14)	/
HS3ST2	cerebral cortex (high), cerebellum, placenta, spleen, lung, stomach, small intestine, colon, testis (13, 14)	anti-oncogenic (15–23) pro-tumoral (24, 25)
HS3ST3A	liver, placenta, spleen, stomach, small intestine, colon, testis, heart, lung, kidney, pancreas (13, 14)	anti-oncogenic (26, 27); pro-tumoral (27)
HS3ST3B	liver (high), placenta (high), spleen (high), stomach, small intestine, colon, testis, skeletal muscle, heart, lung, kidney, pancreas (13, 14)	pro-tumoral (25, 28–31)
HS3ST4	cerebral cortex (high), cerebellum, stomach, spleen, testis (13, 14)	pro-tumoral (25, 32)
HS3ST5	skeletal muscle (high), placenta, cerebral cortex, cerebellum, small intestine, colon (13, 33, 34)	/
HS3ST6	liver, kidney (35)	/