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. 2019 Jun 12;10:1225. doi: 10.3389/fmicb.2019.01225

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Copyright © 2019 Araya, Benites, Reyes, Marcoleta, Valderrama, Lagos and Monasterio.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme for the mechanism of open rings and cylinders formation induced by dNAK 4. Schematic representation of dNAK 4 effect on BsFtsZ polymerization. The filaments induced by GTP to explain the mechanism of inhibition of the polymerization of BsFtsZ produced by dNAK 4 is included. BsFtsZ-GDP form is indicated with gray spheres and the BsFtsZ-GTP form with black spheres. The scheme shows cylinder formation induced by GDP and the loss of protein suitable for filament formation, due to “sequestration” into the cylinders and their precursors.