Table 1.

Inhibition of EcFtsZ polymerization (IFP) and LogP for dNAKs 1–5.

dNAK	Structure	IFPa (μM)	Log P
1		100b	3.9 ± 0.4
2		44b	3.9 ± 0.8
3		39b	3.0 ± 0.4
4		2.3 ± 0.1c 4.4 ± 0.6d	2.4 ± 0.4
5		81.5b	4.3 ± 0.4

^aIFP is expressed as IC₅₀ (μM).

^bIFP was calculated from the EcFtsZ polymerization inhibition by the compounds.

^cIFP was calculated from EcFtsZ slope of light scattering increment produced by the compound after depolymerization. The PK/PEP GTP regeneration system was used (Margalit et al., 2004).

^dIFP was calculated from steady-state slope of light scattering increment produced by the compound. The PK/PEP GTP regeneration system was used.