Table 2. Association of Medical Therapy With Postdischarge 30-Day Neurologic Events After Propensity Score Matchinga.
Outcome | Dual Antiplatelet Therapyb | Oral Anticoagulantc | Dual Antiplatelet Therapy vs Oral Anticoagulantd | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HR (95% CI) | Absolute Risk, % | P Value | HR (95% CI) | Absolute Risk, % | P Value | HR (95% CI) | Absolute Risk, % | P Value | ||||
Yes | No | Yes | No | Dual Antiplatelet Therapy | Oral Anticoagulant | |||||||
Femoral Cohort | ||||||||||||
No. | 31 192 | 22 022 | 24 668 | |||||||||
30-d stroke | 1.04 (0.74-1.46) | 0.55 | 0.52 | .81 | 1.03 (0.73-1.46) | 0.57 | 0.55 | .87 | 1.09 (0.79-1.52) | 0.55 | 0.51 | .59 |
30-d TIA | 0.87 (0.51-1.49) | 0.18 | 0.21 | .61 | 0.84 (0.46-1.52) | 0.19 | 0.24 | .56 | 0.83 (0.49-1.40) | 0.21 | 0.25 | .48 |
30-d stroke or TIA | 0.99 (0.74-1.33) | 0.73 | 0.73 | .96 | 0.98 (0.73-1.33) | 0.76 | 0.77 | .92 | 0.99 (0.75-1.30) | 0.74 | 0.76 | .92 |
Nonfemoral Cohort | ||||||||||||
No. | 6338 | 4608 | 5550 | |||||||||
30-d stroke | 1.02 (0.54-1.95) | 0.71 | 0.69 | .94 | 0.93 (0.47-1.83) | 0.75 | 0.82 | .83 | 0.84 (0.44-1.64) | 0.63 | 0.75 | .62 |
30-d TIA | 0.61 (0.22-1.72) | 0.17 | 0.28 | .35 | 1.31 (0.29-5.84) | 0.18 | 0.15 | .72 | 0.62 (0.20-1.90) | 0.19 | 0.32 | .40 |
30-d stroke or TIA | 0.87 (0.49-1.57) | 0.84 | 0.97 | .65 | 0.98 (0.52-1.87) | 0.94 | 0.97 | .96 | 0.74 (0.41-1.34) | 0.78 | 1.06 | .33 |
Abbreviations: HR, hazard ratio; TIA, transient ischemic attack.
Characteristics of patients in the propensity-matched analyses are provided in eTables 7 through 12 in the Supplement. All medications for the propensity-matched analyses were based on discharge medications.
Patients taking single-antiplatelet therapy were eligible to be included in the no dual antiplatelet therapy group. Patients taking oral anticoagulants were eligible for either group.
Patients taking any antiplatelet regimen were eligible for either group.
Only patients taking dual antiplatelet therapy without oral anticoagulants were eligible for the dual antiplatelet therapy group and patients taking oral anticoagulants with single antiplatelet therapy but no dual antiplatelet therapy were eligible for the oral anticoagulant group.