Table 1.
Baseline characteristics of the three HCV cohorts of TNHIRD.
| (1) |
(2) |
(3) |
p values |
|||
|---|---|---|---|---|---|---|
| HCV-treated | HCV-untreated | HCV-uninfected | (1)–(2) | (1)–(3) | (2)–(3) | |
| n | 7545 | 30,180 | 30,180 | |||
| Gender, n (%) | ||||||
| Male | 4023 (53.32) | 16,092 (53.32) | 16,092 (53.32) | 1 | 1 | 1 |
| Female | 3522 (46.68) | 14,088 (46.68) | 14,088 (46.68) | |||
| Age (mean ± SD), years | 49.68 ± 10.76 | 49.73 ± 11.25 | 49.12 ± 48.98 | |||
| Age range, years, n (%) | ||||||
| 20–39 | 1433 (18.99) | 5714 (18.93) | 5732 (18.99) | 0.9993 | 1 | 0.9973 |
| 40–49 | 2107 (27.93) | 8446 (27.99) | 8428 (27.93) | |||
| 50–59 | 2655 (35.19) | 10,620 (35.19) | 10,620 (35.19) | |||
| ⩾60 | 1350 (17.89) | 5400 (17.89) | 5400 (17.89) | |||
| Area, n (%) | ||||||
| City | 1798 (23.83) | 7174 (23.77) | 7192 (23.83) | 0.9933 | 1 | 0.9833 |
| Township | 2334 (30.93) | 9350 (30.98) | 9336 (30.93) | |||
| Rural area | 3413 (45.24) | 13,656 (45.25) | 13,652 (45.24) | |||
| CCI score, n (%) | ||||||
| 0 | 3815 (50.56) | 15,260 (50.56) | 15,260 (50.56) | 0.9995 | 1 | 0.9987 |
| 1 | 2610 (34.59) | 10,444 (34.61) | 10,440 (34.59) | |||
| ⩾2 | 1120 (14.84) | 4476 (14.83) | 4480 (14.84) | |||
| Index year, n (%) | ||||||
| 2003–2006 | 3683 (48.81) | 14,736 (48.83) | 14,732 (48.81) | 0.9989 | 1 | 0.9973 |
| 2007–2009 | 2464 (32.66) | 9859 (32.67) | 9856 (32.66) | |||
| 2010–2012 | 1398 (18.53) | 5585 (18.51) | 5592 (18.53) | |||
| Baseline factor, n (%) | ||||||
| Liver cirrhosis | 669 (8.87) | 1427 (4.73) | 13 (0.04) | <0.0001 | <0.0001 | <0.0001 |
| COPD | 846 (11.21) | 3422 (11.34) | 2851 (9.45) | 0.7575 | <0.0001 | <0.0001 |
| ESRD | 41 (0.54) | 635 (2.1) | 80 (0.27) | <0.0001 | 0.0001 | <0.0001 |
| DM | 1336 (17.71) | 6539 (21.67) | 5451 (18.06) | <0.0001 | 0.4733 | <0.0001 |
| Hypertension | 2155 (28.56) | 10,285 (34.08) | 7984 (26.45) | <0.0001 | 0.0002 | <0.0001 |
| Dyslipidemia | 913 (12.1) | 5964 (19.76) | 5354 (17.74) | <0.0001 | <0.0001 | <0.0001 |
| Cardiovascular events* | 175 (2.32) | 1218 (4.04) | 746 (2.47) | <0.0001 | 0.4429 | <0.0001 |
| Stroke | 225 (2.98) | 1410 (4.67) | 1460 (4.84) | <0.0001 | <0.0001 | 0.3389 |
| HP infection | 182 (2.41) | 544 (1.8) | 480 (1.59) | 0.0009 | <0.0001 | 0.047 |
| HP therapy | 55 (0.73) | 140 (0.46) | 116 (0.38) | 0.0053 | 0.0002 | 0.1496 |
*
Cardiovascular events including percutaneous coronary intervention, coronary artery bypass graft, myocardial infarction, heart failure, cardiogenic shock, and peripheral vascular disease.
CCI, Charlson Comorbidity Index; COPD, chronic obstructive pulmonary disease; DM, diabetes; ESRD, end-stage renal disease; HCV, hepatitis C virus; HP, Helicobacter pylori; SD, standard deviation; TNHIRD, Taiwan National Health Insurance Research Database.